Healthcare 5.0 integrates Artificial Intelligence (AI), the Internet of Things (IoT), real-time monitoring, and human-centered design toward personalized medicine and predictive diagnostics. However, the increasing reliance on interconnected medical technologies exposes them to cyber threats. Meanwhile, current AI-driven cybersecurity models often neglect biomedical data, limiting their effectiveness and interpretability. This study addresses this gap by applying eXplainable AI (XAI) to a Healthcare 5.0 dataset that integrates network traffic and biomedical sensor data. Classification outputs indicate that XGBoost achieved 99% F1-score for benign and data alteration, and 81% for spoofing. Explainability findings reveal that network data play a dominant role in intrusion detection whereas biomedical features contributed to spoofing detection, with temperature reaching a Shapley values magnitude of 0.37.

Tensor decomposition has emerged as a powerful framework for feature extraction in multi-modal biomedical data. In this review, we present a comprehensive analysis of tensor decomposition methods such as Tucker, CANDECOMP/PARAFAC, spiked tensor decomposition, etc. and their diverse applications across biomedical domains such as imaging, multi-omics, and spatial transcriptomics. To systematically investigate the literature, we applied a topic modeling-based approach that identifies and groups distinct thematic sub-areas in biomedicine where tensor decomposition has been used, thereby revealing key trends and research directions. We evaluated challenges related to the scalability of latent spaces along with obtaining the optimal rank of the tensor, which often hinder the extraction of meaningful features from increasingly large and complex datasets. Additionally, we discuss recent advances in quantum algorithms for tensor decomposition, exploring how quantum computing can be leveraged to address these challenges. Our study includes a preliminary resource estimation analysis for quantum computing platforms and examines the feasibility of implementing quantum-enhanced tensor decomposition methods on near-term quantum devices. Collectively, this review not only synthesizes current applications and challenges of tensor decomposition in biomedical analyses but also outlines promising quantum computing strategies to enhance its impact on deriving actionable insights from complex biomedical data.

Time roots in applying language models for biomedical applications: models are trained on historical data and will be deployed for new or future data, which may vary from training data. While increasing biomedical tasks have employed state-of-the-art language models, there are very few studies have examined temporal effects on biomedical models when data usually shifts across development and deployment. This study fills the gap by statistically probing relations between language model performance and data shifts across three biomedical tasks. We deploy diverse metrics to evaluate model performance, distance methods to measure data drifts, and statistical methods to quantify temporal effects on biomedical language models. Our study shows that time matters for deploying biomedical language models, while the degree of performance degradation varies by biomedical tasks and statistical quantification approaches. We believe this study can establish a solid benchmark to evaluate and assess temporal effects on deploying biomedical language models.

Tabular biomedical data poses challenges in machine learning because it is often high-dimensional and typically low-sample-size. Previous research has attempted to address these challenges via feature selection approaches, which can lead to unstable performance on real-world data. This suggests that current methods lack appropriate inductive biases that capture patterns common to different samples. In this paper, we propose ProtoGate, a prototype-based neural model that introduces an inductive bias by attending to both homogeneity and heterogeneity across samples. ProtoGate selects features in a global-to-local manner and leverages them to produce explainable predictions via an interpretable prototype-based model. We conduct comprehensive experiments to evaluate the performance of ProtoGate on synthetic and real-world datasets. Our results show that exploiting the homogeneous and heterogeneous patterns in the data can improve prediction accuracy while prototypes imbue interpretability.

The volume of open-source biomedical data has been essential to the development of various spheres of the healthcare community since more `free' data can provide individual researchers more chances to contribute. However, institutions often hesitate to share their data with the public due to the risk of data exploitation by unauthorized third parties for another commercial usage (e.g., training AI models). This phenomenon might hinder the development of the whole healthcare research community. To address this concern, we propose a novel approach termed `unlearnable biomedical image' for protecting biomedical data by injecting imperceptible but delusive noises into the data, making them unexploitable for AI models. We formulate the problem as a bi-level optimization and propose three kinds of anti-learning perturbation generation approaches to solve the problem. Our method is an important step toward encouraging more institutions to contribute their data for the long-term development of the research community.

Biomedical data and benchmarks are highly valuable yet very limited in low-resource languages other than English such as Vietnamese. In this paper, we make use of a state-of-the-art translation model in English-Vietnamese to translate and produce both pretrained as well as supervised data in the biomedical domains. Thanks to such large-scale translation, we introduce ViPubmedT5, a pretrained Encoder-Decoder Transformer model trained on 20 million translated abstracts from the high-quality public PubMed corpus. ViPubMedT5 demonstrates state-of-the-art results on two different biomedical benchmarks in summarization and acronym disambiguation. Further, we release ViMedNLI - a new NLP task in Vietnamese translated from MedNLI using the recently public En-vi translation model and carefully refined by human experts, with evaluations of existing methods against ViPubmedT5.

TetraScience, the Scientific Data Cloud company, announced today that Elucidata, whose data-centric platform Polly powers biological discovery with ML-ready biomedical data, has joined the Tetra Partner Network to accelerate the use of Machine Learning (ML) in life sciences R&D, with the Tetra Scientific Data Cloud . "Where machine learning has encountered large-scale, organized scientific data sets, fundamental breakthroughs have been derived," said Alan Millar, Ph.D., V.P., Tetra Partner Network. "By combining over 1.5 million ML-ready datasets curated by Polly with contextualized experimental data from the Tetra Scientific Data Cloud, our partnership accelerates data-driven discoveries. Successful ML initiatives are built on high-quality data. Elucidata's Polly provides access to clean and curated biomedical datasets fit for any tool, pipeline, or ML model.

Author summary Interest in machine learning as applied to challenges in medicine has seen an exponential rise over the past decade. A key issue in developing machine learning models is the availability of sufficient high-quality data. Another related issue is a requirement to validate a locally trained model on data from external sources. However, sharing sensitive biomedical and clinical data across different hospitals and research teams can be challenging due to concerns with data privacy and data stewardship. These issues have led to innovative new approaches for collaboratively training machine learning models without sharing raw data. One such method, termed ‘federated learning,’ enables investigators from different institutions to combine efforts by training a model locally on their own data, and sharing the parameters of the model with others to generate a central model. Here, we systematically review reports of successful deployments of federated learning applied to research problems involving biomedical data. We found that federated learning links research teams around the world and has been applied to modelling in such as oncology and radiology. Based on the trends we observed in the studies reviewed in our paper, we observe there are opportunities to expand and improve this innovative approach so global teams can continue to produce and validate high quality machine learning models.

Artificial intelligence (AI) is a broad and evolving scientific field, and the value it can deliver at various stages of the drug discovery process is now widely accepted in the pharmaceutical industry. This blog seeks to demystify the application of AI in drug discovery, focusing on its key challenges, opportunities and successes. Over one million scientific articles are published every year in the biomedical domain alone, and every new year brings new methods for data collection and more detailed data modalities. While scientists have access to an exponentially increasing amount of knowledge and data, biological data is messy and incomplete; it may contain conflicting or contradicting evidence, suppositions, biases, uncertainty, gaps in knowledge or misclassifications. This prevents us from understanding the full biology landscape and complicates decision making.

With the rapid development of biomedical software and hardware, a large amount of relational data interlinking genes, proteins, chemical components, drugs, diseases, and symptoms has been collected for modern biomedical research. Many graph-based learning methods have been proposed to analyze such type of data, giving a deeper insight into the topology and knowledge behind the biomedical data, which greatly benefit to both academic research and industrial application for human healthcare. However, the main difficulty is how to handle high dimensionality and sparsity of the biomedical graphs. Recently, graph embedding methods provide an effective and efficient way to address the above issues. It converts graph-based data into a low dimensional vector space where the graph structural properties and knowledge information are well preserved. In this survey, we conduct a literature review of recent developments and trends in applying graph embedding methods for biomedical data. We also introduce important applications and tasks in the biomedical domain as well as associated public biomedical datasets.